health
December 15, 2025
AlphaGenome: AI for better understanding the genome
Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.
TL;DR
- AlphaGenome is a new AI tool for predicting the impact of DNA variants on gene regulation.
- It can process long DNA sequences (up to 1 million base-pairs) with high resolution.
- The model predicts diverse molecular properties, including gene start/end locations, RNA production, and DNA accessibility.
- AlphaGenome can efficiently score the impact of genetic variants by comparing mutated and unmutated sequences.
- It introduces novel splice-junction modeling, offering deeper insights into RNA splicing consequences of variants.
- The tool achieves state-of-the-art performance across various genomic prediction benchmarks.
- AlphaGenome is available via API for non-commercial research use.
- Potential applications include disease understanding, synthetic biology, and fundamental genomic research.
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