Could a vaccine prevent dementia? Shingles shot data only getting stronger.

February 26, 2026

TL;DR

Studies indicate that individuals vaccinated against shingles have a lower risk of dementia.
Recent research suggests the shingles vaccine may also slow biological aging and reduce inflammation markers.
The effectiveness of the newer Shingrix vaccine in preventing dementia may be greater than the older Zostavax vaccine.
Natural experiments comparing vaccinated and unvaccinated groups have strengthened the link between shingles vaccination and reduced dementia risk.
Researchers speculate that the vaccine's benefit may stem from fortifying immune responses and reducing overall brain inflammation.
Some studies show greater dementia risk reduction for women compared to men, though the reason is unclear.
Vaccinated individuals in one study showed lower signs of inflammation and molecular aging.

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