AlphaGenome 2: Predicting how DNA shapes cells and disease
AlphaGenome 2 is our next-generation DNA sequence model that bridges single-cell biology and human genetics, predicting how variants affect human cell types.
TL;DR
- AlphaGenome 2 is a next-generation DNA sequence model that predicts the impact of genetic variants on specific human cell types.
- It improves upon previous models by adopting a conditional architecture that allows for predictions tailored to individual cell types and states.
- The model demonstrates nearly twice the performance in identifying variants that change gene expression in cells compared to its predecessor.
- AlphaGenome 2 can generalize to new, unseen cell states from single-cell data without requiring retraining.
- The model predicts gene expression, histone modifications, chromatin accessibility, and DNA methylation.
- It aids in mapping enhancer-gene links and pinpointing causal variants from genome-wide association studies (GWAS) in relevant cell types.
- AlphaGenome 2 is available for non-commercial research via API and in private preview for commercial research.